General
Preferred name
ZALCITABINE
Synonyms
2',3'-dideoxycytidine ()
DIDEOXYCYTIDINE ()
ddC ()
NSC 606170 ()
Ro 24-2027/000 ()
NSC 606170, Ro 24-2027/000 ()
Ddc (ddc) ()
Hivid ()
Ro-24-2027000 ()
Ro-242027000 ()
NSC-606170 ()
Zalcitabine (dideoxycytidine,ddc) ()
P&D ID
PD001308
CAS
7481-89-2
Tags
prodrug
probe
natural product
drug
available
Approved by
FDA
First approval
1992
Drug Status
investigational
approved
withdrawn
Drug indication
Human immunodeficiency virus infection
Antiviral
Max Phase
Phase 4
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NRTI) antiretroviral drug. Chemically it is an is an analogue of pyrimidine and is a derivative of endogenous deoxycytidine.
(GtoPdb)
DESCRIPTION
Nucleoside analog; reverse transcriptase inhibitor; antiviral
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
7
Compound Sets
29
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
211.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.5
TPSA
90.37
Fraction CSP3
0.56
Chiral centers
2.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reverse Transcriptase
MOA
viral reverse transcriptase inhibitor
nucleoside reverse transcriptase inhibitor
Target
Human immunodeficiency virus type 1 reverse transcriptase
HIV
Pathway
Microbiology&virology
Proteases/Proteasome
Anti-infection
Indication
human immunodeficiency virus (HIV-1)
ATC
J05AF03
Therapeutic Class
Anti-HIV Agents
Source data
