General
Preferred name
AMLEXANOX
Synonyms
Amoxanox ()
CHX3673 ()
AA673 ()
Solfa ()
Amlexanox (AA-673) ()
CHX-3673, Amoxanox ()
Aphtheal ()
CHX 3673 ()
CHX-3673 ()
AA-673 ()
Aphthasol ()
Elics ()
P&D ID
PD001296
CAS
68302-57-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1996
Drug Status
investigational
approved
withdrawn
Drug indication
Respiratory tract inflammation
Anti-Allergic
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Amlexanox has anti-inflammatory , antiallergic and immunomodulatory actions . Proposed to inhibit IKKδ and TBK1, albeit with low potency .
(GtoPdb)
DESCRIPTION
Inhibitor of TBK1 and IKKepsilon; antiallergic agent
(Tocriscreen Plus)
DESCRIPTION
Selective UBE2N inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
27
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
JUMP-Target 1 Compound Set
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
298.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.75
TPSA
106.42
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
NF-¦ÊB
Angiogenesis
Immunology/Inflammation
Tyrosine Kinase/Adaptors
NF-??b
NF-??
NF-κB
Target
FGFR1
IL-3
Protein S100-P
IKK??
TBK1
TBK1,IKK-??
FGF1, IL3, PDE4A, PDE4B, PDE4C, PDE4D, S100A12, S100A13
FGF1
IKK
Immunology & Inflammation related,I¦ÊB/IKK,TBK1
Primary Target
TANK Binding Kinase
MOA
Inhibitor
Mediator Release Inhibitors
histamine receptor modulator
Member status
member
Indication
aphthous ulcers, asthma, conjunctivitis, allergic rhinitis
Disease Area
dental, pulmonary, ophthalmology, allergy
Biosynthetic Origin
Polyketide (Aromatic)
Therapeutic Indication
Antiasthmatic
Therapeutic Class
Respiratory
Antiulcer Agents
Source data
