General
Preferred name
SILDENAFIL CITRATE
Synonyms
UK-92480 citrate ()
Sildenafil (citrate) ()
UK-92480 (citrate) ()
UK-92480-10 ()
NSC-744009 ()
Revatio ()
Viagra ()
NSC-758669 ()
Sildenafil (as citrate) ()
UK-92,480-10 ()
P&D ID
PD001286
CAS
171599-83-0
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Impotence Therapy
First approval
1998
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Orally active, potent PDE5 inhibitor
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
12
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
666.23
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
5
Rotatable Bonds
12
Ring Count
4
Aromatic Ring Count
3
cLogP
0.36
TPSA
245.55
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Metabolism
Anti-infection
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Target
PDE5
PDE6
PDE5 inhibitor
Bacterial
Phosphodiesterase (PDE)
PDE
Source data
