General
Preferred name
TEPOXALIN
Synonyms
RWJ 20485 ()
Zubrin ()
RWJ-20485 ()
ORF-20485 ()
ORF 20485 ()
P&D ID
PD001282
CAS
103475-41-8
03475-41-8
Tags
available
drug
Drug Status
approved
vet_approved
Approved by
FDA
Drug indication
Antipsoriatic
Asthma
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase and may be used to treat asthma and osteoarthritis (OA).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugMAP
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
385.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.98
TPSA
67.59
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Cyclooxygenase (COX) Inhibitors
Lipoxygenase Inhibitors
NF-kappaB (NFKB) Activation Inhibitors
cyclooxygenase inhibitor, lipoxygenase inhibitor
Indication
rheumatoid arthritis, hip dysplasia
Disease Area
rheumatology, orthopedics
Target
ALOX5
COX
Lipoxygenase
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Solubility
Soluble in DMF (30 mg/ml), DMSO (30 mg/ml), Ethanol (15 mg/ml)
Source data
