General
Preferred name
BUTOCONAZOLE
Synonyms
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole ()
RS 35887 ()
BUTOCONAZOLE NITRATE ()
Butoconazole (nitrate) ()
RS-35887 ()
NSC-758658 ()
Butoconazol ()
Gynofort ()
RS-35887-00-10-3 ()
Femstat ()
Femstat 3 ()
Gynazole-1 ()
Gynazole ()
P&D ID
PD001266
CAS
64872-77-1
64872-76-0
67085-14-7
67085-13-6
32872-77-1
Tags
available
drug
Approved by
FDA
First approval
1985
1995
Drug indication
vulvovaginitis
Candidiasis
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis[1][2].
PRICE 39
DESCRIPTION Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis[1][2].
PRICE 29
DESCRIPTION Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent (TargetMol Bioactive Compound Library)
DESCRIPTION Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
18
Cayman Chemical Bioactives
23554
ChEMBL Approved Drugs
CHEMBL1295
CHEMBL1200398
ChEMBL Drugs
CHEMBL1295
CHEMBL1200398
DrugBank
DB00639
DrugBank Approved Drugs
DB00639
DrugCentral
450
DrugCentral Approved Drugs
450
DrugMAP
DM8SY60
DrugMAP Approved Drugs
DM8SY60
DrugMatrix
MedChem Express Bioactive Compound Library
HY-B0293A
HY-B0293
NCATS Inxight Approved Drugs
0Q771797PH
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
butoconazole
butoconazole-nitrate
TargetMol Bioactive Compound Library
T8490
T1438
The Spectrum Collection
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
410.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
6.64
TPSA
17.82
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Endocrinology/Hormones
Anti-infection
MOA
Estrogen/progestogen Receptor inhibitor
Target
Fungal
Fungal,IFN,Interleukins,TNF-alpha
Antifungal
ER
Therapeutic Class
Antifungal Agents
Source data