General
Preferred name
NILUTAMIDE
Synonyms
1-(3'-Trifluoromethyl-4'-nitrophentyl)-4,4-dimethylimidazoline 2,5-dione ()
RU23908 ()
Nilandron ()
RU 23908 ()
Anadron ()
RU-23908 ()
NSC-758683 ()
Nilutamide-d6 ()
P&D ID
PD001255
CAS
63612-50-0
1189477-66-4
Tags
available
drug
Approved by
FDA
First approval
1996
Drug Status
investigational
approved
Drug indication
Antineoplastic
Prostate cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nilutamide is a synthetic, non-steroidal, pure antiandrogen. (GtoPdb)
DESCRIPTION Antiandrogen (LOPAC library)
DESCRIPTION Androgen receptor antagonist. Orally active (Tocriscreen Total)
Compound Sets
30
Axon Medchem Screening Library
3249
Cayman Chemical Bioactives
23953
28694
ChEMBL Approved Drugs
CHEMBL1274
ChEMBL Drugs
CHEMBL1274
Concise Guide to Pharmacology 2017/18
2864
Concise Guide to Pharmacology 2019/20
2864
Concise Guide to Pharmacology 2021/22
2864
Concise Guide to Pharmacology 2023/24
2864
Drug Repurposing Hub
DrugBank
DB00665
DrugBank Approved Drugs
DB00665
DrugCentral
1933
DrugCentral Approved Drugs
1933
DrugMAP
DMFN07X
DrugMAP Approved Drugs
DMFN07X
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
2864
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1274
MedChem Express Bioactive Compound Library
HY-13702
NCATS Inxight Approved Drugs
51G6I8B902
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FLG99DJZ3Z3
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nilutamide
TargetMol Bioactive Compound Library
T0272
The Spectrum Collection
Tocriscreen Total
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
317.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
2.45
TPSA
92.55
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Androgen
Pathway
Endocrinology/Hormones
Anti-infection
Vitamin D Related/Nuclear Receptor
Target
Androgen Receptor
AR
AR antagonist
Parasite
Indication
prostate cancer
MOA
Androgen Receptor antagonist
Therapeutic Class
Anticancer Agents
Source data