General
Preferred name
NORCANTHARIDIN
Synonyms
Norcantharadine ()
Endothall anhydride ()
(Rac)-Norcantharidin ()
(Rac)-NCTD ()
(±)-Norcantharidin ()
DEMETHYL-CANTHARIDIN ()
(??)-Norcantharidin ()
P&D ID
PD001254
CAS
5442-12-6
29745-04-8
51154-98-4
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (Rac)-Norcantharidin ((Rac)-NCTD) is the isoform of Norcantharidin, which is a synthetic and demethylated anticancer agent derived from Cantharidin (HY-N0209). Norcantharidin has lighter side effects and stronger bioactivity than Cantharidin. And Norcantharidin inhibits cell proliferation, migration and metastasis, and causes apoptosis and autophagy[1][2].
PRICE 29
PRICE 30
DESCRIPTION (??)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.
DESCRIPTION Demethylated form of cantharidin with antitumor properties; potent inhibitor of the serine/threonine protein phosphatase 2A (PP2A) (LOPAC library)
DESCRIPTION Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. (TargetMol Bioactive Compound Library)
DESCRIPTION (±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. (TargetMol Bioactive Compound Library)
Cell lines
20
Organisms
1
Compound Sets
7
DrugMAP
DM9B6Y1
LOPAC library
MedChem Express Bioactive Compound Library
HY-N0585
ReFrame library
Selleckchem Bioactive Compound Library
rac-norcantharidin
norcantharidin
TargetMol Bioactive Compound Library
T5656
T2894
The Spectrum Collection
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
168.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
0
cLogP
-0.14
TPSA
52.6
Fraction CSP3
0.75
Chiral centers
4.0
Largest ring
5.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PP2A
Target
c-Met
EGFR
Apoptosis
c-Met,EGFR
Endogenous Metabolite
MOA
c-Met/HGFR
Pathway
Angiogenesis
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Metabolic Enzyme/Protease
Source data