General
Preferred name
FLUOXETINE HYDROCHLORIDE
Synonyms
Fluoxetine HCl ()
LY-110140 ()
Lilly110140 ()
Fluoxetine (HCl) ()
Prozac, Sarafem,LY-110140 ()
Fluoxetine (Lilly 110140) HCl ()
Fluoxetine (hydrochloride) ()
Fluoxetine hydrochloride component of symbyax ()
SARAFEM ()
FLUCTIN ()
FLUSOL ()
OXACTIN ()
PROZAC WEEKLY ()
OLENA ()
FLUOXEREN ()
PROZAC ()
FLUOX-PUREN ()
PROZAC 60 ()
PROZIT ()
FONTEX ()
SELFEMRA ()
ADOFEN ()
RANFLUTIN ()
LOVAN ()
FELICIUM ()
LY110140 ()
PROZEP ()
FLUNEURIN ()
FLUXET ()
FLUOXETINE (AS HYDROCHLORIDE) ()
FOXETIN ()
RECONCILE ()
Prozac(R) ()
FLUOXETINE ()
Fluoxetine (hydrochloride) (CRM) ()
FLUOXETINE HYDROCHLORIDE COMPONENT OF SYMBYAX ()
P&D ID
PD001248
CAS
56296-78-7
59333-67-4
Tags
available
drug
nuisance
Drug Status
approved
Max Phase
4.0
Drug indication
panic disorder
First approval
1987
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Fluoxetine HCl is a selective serotonin reuptake inhibitor. Fluoxetine HCl have been used in the treatment of major depression as well as other psychiatric disorders. (Enamine Bioactive Compounds)
DESCRIPTION Selective serotonin reuptake inhibitor (LOPAC library)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Plus)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Total)
DESCRIPTION Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. (TargetMol Bioactive Compound Library)
DESCRIPTION sigma1 selective antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
20
Axon Medchem Screening Library
1302
Cayman Chemical Bioactives
32720
14418
ChEMBL Approved Drugs
CHEMBL1201082
ChEMBL Drugs
CHEMBL1201082
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EBC-03850
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101181
EUbOPEN Chemogenomics Library
EUB0000428
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201082
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Fluoxetine-hydrochloride
TargetMol Bioactive Compound Library
T0450L
The Spectrum Collection
Tocris Bioactive Compound Library
0927
Tocriscreen Plus
0927
Tocriscreen Total
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
345.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
4.86
TPSA
21.26
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Selectivity
Reuptake
Pathway
Autophagy
GPCR/G protein
Neuroscience
Primary Target
5-HT Transporters
MOA
Inhibitor
Target
SSRI
5-HT Receptor
5-HT
Serotonin Transporter
Sert (Sodium-dependent)
Recommended Cell Concentration
1 uM
Source data