General
Preferred name
METAXALONE
Synonyms
Carnrick brand of metaxalone ()
Skelaxin ()
Methaxalonum ()
Zorane ()
NSC170959 ()
AHR438 ()
Skelaxin, Methaxalonum, Zorane ()
Metaxalone ()
NSC-170959 ()
AHR-438 ()
Metaxalona ()
Flexura ()
Metaxalone-d6 ()
P&D ID
PD001220
CAS
1665-48-1
105801-80-7
1189944-95-3
Tags
available
drug
Approved by
FDA
First approval
1962
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY LD50=775mg/kg (Rat, oral); LD50=1690 mg/kg (Mouse, oral). When determining the LD50 in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes. Some adverse events associated with the drug include nausea, vomiting, drowsiness and CNS side effects such as dizziness, headache, and irritability.
DESCRIPTION Metaxalone is a racemic mixture of two enantiomers; R-metaxalone and S-metaxalone. We show the non-stereo structure to represent the mixture. (GtoPdb)
DESCRIPTION Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1¦Â-induced inflammatory phenotype, modulates NF-¦ÊB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1¦Â-treated microglia[1][2].
PRICE 29
DESCRIPTION Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. (Enamine Bioactive Compounds)
DESCRIPTION Metaxalone (Methaxalonum) (marketed by King Pharmaceuticals under the brand name Skelaxin ) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. (TargetMol Bioactive Compound Library)
Compound Sets
20
Cayman Chemical Bioactives
15777
33377
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1079604
ChEMBL Drugs
CHEMBL1079604
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00660
DrugBank Approved Drugs
DB00660
DrugCentral
1722
DrugCentral Approved Drugs
1722
DrugMatrix
Enamine Bioactive Compounds
EBC-06028
Enamine BioReference Compounds
Guide to Pharmacology
7609
MedChem Express Bioactive Compound Library
HY-B0678
NCATS Inxight Approved Drugs
1NMA9J598Y
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
metaxalone
TargetMol Bioactive Compound Library
T1610
The Spectrum Collection
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
221.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.79
TPSA
47.56
Fraction CSP3
0.42
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
Target
NF-κB
PGC-1α
PGC-1¦Á
Pathway
Metabolic Enzyme/Protease
NF-¦ÊB
Source data