General
Preferred name
HYDROQUINONE
Synonyms
Formaldehyde-hydroquinone polymer ()
Quinol ()
1,4-Benzenediol ()
1,4-Dihydroxybenzene ()
HQ ()
CHEBI:17594 ()
CHEMBL537 ()
Eldoquin forte ()
Black and white bleaching cream ()
Eldopaque forte ()
Hydroquinone component of tri-luma ()
NCI-C55834 ()
Solaquin forte ()
NSC-9247 ()
P&D ID
PD001215
CAS
123-31-9
Tags
available
drug
Approved by
FDA
First approval
2002
Drug indication
Melasma
freckles
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Arachidonate 12-Lipoxygenase inhibitor
(LOPAC library)
DESCRIPTION
Hydroquinone is a topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles. Hydroquinone reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
2
Compound Sets
18
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
59
Molecular Weight
110.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
1.1
TPSA
40.46
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
.
Arachidonate 12-Lipoxygenase
Indication
dyschromia
Target
TYR
MOA
melanin inhibitor
Source data
