General
Preferred name
LEVOFLOXACIN
Synonyms
Levofloxacin (-)-ofloxacin ()
Levaquin hydrate ()
Cravit hydrate ()
Quixin hydrate ()
Levofloxacin Hemihydrate ()
Tavanic hydrate ()
Iquix hydrate ()
Levaquin ()
Cravit ()
Tavanic ()
Fluoroquinolone ()
(-)-Ofloxacin ()
Levofloxacin hydrate ()
LEVOFLOXACIN ANHYDROUS ()
LEVOFLOXACINN/A ()
Levofloxacin (hydrate) ()
Levofloxacin (hydrochloride) ()
(-)-Ofloxacin (hydrochloride) ()
LEVOFLOXACIN HYDROCHLORIDE ()
Levofloxacin (anhydrous) ()
NSC-758709 ()
Levofloxacino (anhydrous) ()
Ofloxacin s-(-)-form ()
Levofloxacine (anhydrous) ()
Quixin ()
L-ofloxacin ()
Levofloxacin (as hemihydrate) ()
DR-3355 ()
RWJ-25213 ()
Quinsair ()
Ofloxacin s-(-)-form hemihydrate ()
Ofloxacin, (s)- ()
Oftaquix ()
Volequin ()
Iquix ()
Evoxil ()
Nofaxin ()
Levofloxacin-d8 (hydrochloride) ()
P&D ID
PD001207
CAS
138199-71-0
100986-85-4
177325-13-2
2699607-50-4
Tags
available
drug
Approved by
FDA
First approval
1996
Drug indication
infection
Chronic bronchitis
Bacterial infection
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibacterial. (GtoPdb)
PRICE 29
DESCRIPTION Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity[1][2][3][4][5].
PRICE 29
DESCRIPTION Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity[1][2][3][4].
PRICE 29
DESCRIPTION Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague. Levofloxacin, like other fluoroquinolone antibiotics, exerts its antimicrobial activity via the inhibition of two key bacterial enzymes: DNA gyrase and topoisomerase IV. (Enamine Bioactive Compounds)
DESCRIPTION Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that inhibits the superhelical activity of bacterial DNA rotamase and prevents DNA replication. Levofloxacin is a broad-spectrum antibiotic used for the treatment of a wide range of bacterial infections. (TargetMol Bioactive Compound Library)
DESCRIPTION Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. (TargetMol Bioactive Compound Library)
DESCRIPTION Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
9
Compound Sets
25
AdooQ Bioactive Compound Library
A10528
A16167
Cayman Chemical Bioactives
20382
29080
ChEMBL Approved Drugs
CHEMBL33
CHEMBL5315124
ChEMBL Drugs
CHEMBL33
CHEMBL5315124
Drug Repurposing Hub
DrugBank
DB01137
DrugBank Approved Drugs
DB01137
DrugCentral
1569
DrugCentral Approved Drugs
1569
DrugMAP
DMS60RB
DrugMAP Approved Drugs
DMS60RB
Enamine Bioactive Compounds
EBC-11226
Enamine BioReference Compounds
Guide to Pharmacology
10911
MedChem Express Bioactive Compound Library
HY-B0330
HY-B0330A
HY-B0330B
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
RIX4E89Y14
NIH Clinical Collections (NCC)
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
levofloxacin-levaquin
TargetMol Bioactive Compound Library
T6567
T1451
T8747
The Pathogen Box
External IDs
86
Properties
(calculated by RDKit )
Molecular Weight
361.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
1.54
TPSA
75.01
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
REFERENCE COMPOUNDS
Target
antibiotic
Bacterial
DNA gyrase
Topo II
Topo IV
TOP2A
DNA/RNA Synthesis
Orthopoxvirus
Topoisomerase
Apoptosis
MOA
DNA gyrase inhibitor
Topoisomerase inhibitor
bacterial DNA gyrase inhibitor
Indication
pneumonia, sinusitis, bronchitis, skin infections, prostatitis, urinary tract infections, pyelonephritis, anthrax, plague
respiratory tract infections, sinusitis, skin infections, bone and joint infections, intra-abdominal infections, diarrhea, fever, urinary tract infections
Disease Area
infectious disease, otolaryngology, gastroenterology, endocrinology
infectious disease, otolaryngology, pulmonary, urology
Therapeutic Indication
Antibacterial
Therapeutic Class
Antimicrobial
Antibiotics
Pathway
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Source data