General
Preferred name
CANDESARTAN CILEXETIL
Synonyms
CANDESARTAN CILEXTIL ()
TCV-116 ()
candesartan cilexetil, GlaxoSmithKline ()
Amias ()
NSC-758697 ()
Atacand ()
Ratacand ()
Candesartan 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester ()
P&D ID
PD001206
CAS
145040-37-5
Tags
available
prodrug
drug
Approved by
PMDA
FDA
First approval
1998
Drug Status
approved
Max Phase
4.0
Drug indication
Hypertension
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure[1][2][3][4][5][6].
PRICE
29
DESCRIPTION
Candesartan cilexetil is an angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy.
(Enamine Bioactive Compounds)
DESCRIPTION
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). Upon hydrolysis to candesartan during gastrointestinal absorption, it selectively competes with angiotensin II for binding to the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation.
(TargetMol Bioactive Compound Library)
DESCRIPTION
5-HT2 agonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
1
Compound Sets
23
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
610.25
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
6
Aromatic Ring Count
5
cLogP
6.32
TPSA
143.34
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.14
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
angiotensin II receptor
Angiotensin Receptor
Apoptosis
AT2 antagonist
Primary Target
Angiotensin AT1 Receptors
MOA
Antagonist
Angiotensin AT1 Antagonists
Member status
member
Pathway
GPCR/G protein
Endocrinology/Hormones
Source data
