General
Preferred name
LOSARTAN
Synonyms
LACIDIPINE ()
Losartan D4 ()
DuP-753 D4 ()
DuP-753 ()
LOSARTAN POTASSIUM ()
MK 954,DuP 753 ()
Losartan Potassium (DuP 753) ()
Losartan-d4 ()
[3H]losartan ()
E-3174 ()
ANGIZAAR ()
HGP1405 ()
Allisartan ()
LOSARTIC ()
LOZAP ()
NSC-758699 ()
HGP-1405 ()
EXP-3174 ()
DUP-89 ()
EXP3174 ()
Losartan Carboxylic Acid ()
P&D ID
PD001204
CAS
124750-99-8
114798-26-4
1030937-27-9
Tags
available
drug
Approved by
FDA
First approval
1995
Drug indication
Discovery agent
Hypertension
Coronavirus Disease 2019 (COVID-19)
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
DESCRIPTION Losartan, an antagonist of angiotensin II receptor, could be effective in the treatment of hypertensive. IC50: 20nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Losartan is an angiotensin receptor blocker. It is used to treat hypertension and diabetic nephropathy, to reduce the risk of stroke. (Enamine Bioactive Compounds)
DESCRIPTION Losartan (DuP-753) is an angiotensin II receptor antagonist. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
37
AdooQ Bioactive Compound Library
A17510
Axon Medchem Screening Library
3102
BOC Sciences Bioactive Compounds
losartan-cas-114798-26-4-item-54987
Cayman Chemical Bioactives
22567
ChEMBL Approved Drugs
CHEMBL191
ChEMBL Drugs
CHEMBL191
Concise Guide to Pharmacology 2017/18
3941
590
Concise Guide to Pharmacology 2019/20
3941
590
Concise Guide to Pharmacology 2021/22
3941
590
Concise Guide to Pharmacology 2023/24
3941
590
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00678
DrugBank Approved Drugs
DB00678
DrugCentral
1610
DrugCentral Approved Drugs
1610
DrugMAP
DM72JXH
DMTL5Q0
DrugMAP Approved Drugs
DM72JXH
DrugMatrix
Enamine Bioactive Compounds
EBC-27042
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101761
EUbOPEN Chemogenomics Library
EUB0000371
Guide to Pharmacology
3941
590
Ki Database
Losartan
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL191
Mcule NIBR MoA Box Subset
MCULE-5204931675
MedChem Express Bioactive Compound Library
HY-17512
NCATS Inxight Approved Drugs
JMS50MPO89
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
losartan
losartan-potassium
TargetMol Bioactive Compound Library
T0215L
The Spectrum Collection
External IDs
86
Properties
(calculated by RDKit )
Molecular Weight
422.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
4
cLogP
4.27
TPSA
92.51
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin Receptor
AT1 receptor
AGTR1
AT2 antagonist
Pathway
GPCR/G protein
Endocrinology/Hormones
Member status
virtual
MOA
AGTR1 gene inhibitor
angiotensin receptor antagonist
Indication
hypertension, diabetic nephropathy, hypertension
Disease Area
cardiology, nephrology
Therapeutic Class
Antihypertensive Agents
Antiviral Agents
Solubility
DMSO 95 mg/mL
Water 95 mg/mL
Recommended Cell Concentration
100 nM
Source data