General
Preferred name
LOSARTAN
Synonyms
LACIDIPINE ()
Losartan D4 ()
DuP-753 D4 ()
DuP-753 ()
LOSARTAN POTASSIUM ()
Losartan Potassium (DuP 753) ()
MK 954,DuP 753 ()
[3H]losartan ()
Allisartan ()
ANGIZAAR ()
HGP-1405 ()
LOZAP ()
EXP-3174 ()
EXP3174 ()
HGP1405 ()
LOSARTIC ()
Losartan Carboxylic Acid ()
E-3174 ()
NSC-758699 ()
DUP-89 ()
Losartan-d4 ()
P&D ID
PD001204
CAS
124750-99-8
114798-26-4
1030937-27-9
Tags
available
drug
Approved by
FDA
First approval
1995
Drug indication
Coronavirus Disease 2019 (COVID-19)
Antihypertensive
Discovery agent
Hypertension
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Losartan, an antagonist of angiotensin II receptor, could be effective in the treatment of hypertensive. IC50: 20nM. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
35
AdooQ Bioactive Compound Library
A17510
Axon Medchem Screening Library
3102
BOC Sciences Bioactive Compounds
losartan-cas-114798-26-4-item-54987
Cayman Chemical Bioactives
22567
ChEMBL Approved Drugs
CHEMBL191
ChEMBL Drugs
CHEMBL191
Concise Guide to Pharmacology 2017/18
3941
590
Concise Guide to Pharmacology 2019/20
3941
590
Concise Guide to Pharmacology 2021/22
3941
590
Concise Guide to Pharmacology 2023/24
3941
590
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00678
DrugBank Approved Drugs
DB00678
DrugCentral
1610
DrugCentral Approved Drugs
1610
DrugMAP
DM72JXH
DMTL5Q0
DrugMAP Approved Drugs
DM72JXH
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101761
EUbOPEN Chemogenomics Library
EUB0000371
Guide to Pharmacology
3941
590
Ki Database
Losartan
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL191
Mcule NIBR MoA Box Subset
MCULE-5204931675
MedChem Express Bioactive Compound Library
HY-17512
NCATS Inxight Approved Drugs
JMS50MPO89
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
losartan
losartan-potassium
The Spectrum Collection
External IDs
85
Properties
(calculated by RDKit )
Molecular Weight
422.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
4
cLogP
4.27
TPSA
92.51
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin Receptor
AGTR1
AT2 antagonist
Pathway
GPCR/G protein
Member status
virtual
MOA
AGTR1 gene inhibitor
angiotensin receptor antagonist
Indication
hypertension, diabetic nephropathy, hypertension
Disease Area
cardiology, nephrology
Therapeutic Class
Antihypertensive Agents
Antiviral Agents
Solubility
DMSO 95 mg/mL
Water 95 mg/mL
Recommended Cell Concentration
None
Source data