General
Preferred name
RAFOXANIDE
Synonyms
Disalan, Ranide, Flukanide, Bovanide ()
Rafoxanida ()
NSC-355278 ()
RAFOXANIDA ()
P&D ID
PD001183
CAS
22662-39-1
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research[1][2][3].
DESCRIPTION Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
6
Compound Sets
10
Cayman Chemical Bioactives
29616
ChEMBL Drugs
CHEMBL287542
EU-OPENSCREEN Bioactive Compound Library
EOS100900
EUbOPEN Chemogenomics Library
EUB0002070
MedChem Express Bioactive Compound Library
HY-17598
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
rafoxanide
TargetMol Bioactive Compound Library
T7093
The Spectrum Collection
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
624.82
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
6.95
TPSA
58.56
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
CDK4
CDK6
Parasite
Apoptosis
Oxidative Phosphorylation
p38 MAPK
Raf
Pathway
Cell Cycle/Checkpoint
Microbiology/virology
Anti-infection
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Recommended Cell Concentration
None
Source data