General
Preferred name
KOJIC ACID
Synonyms
5-Hydroxy-2-(hydroxymethyl)-4h-pyran-4-one ()
5-Hydroxy-2-(hydroxymethyl)-4-pyrone ()
P&D ID
PD001182
CAS
123712-78-7
501-30-4
Tags
available
drug
Drug indication
Discovery agent
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 ¦ÌM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-¦ÊB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity[1][2][3][4][5][6][7][8].
PRICE 29
DESCRIPTION Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 ??M for mushroom tyrosinase.
DESCRIPTION Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae. In skin care products, kojic acid functions primarily as a skin-lightening agent. It is a potent tyrosinase inhibitor. Kojic acid also has antibacterial and antifungal properties. (Enamine Bioactive Compounds)
DESCRIPTION Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 μM for mushroom tyrosinase. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
12
Cayman Chemical Bioactives
22712
DrugBank
DB01759
DrugCentral
3977
DrugCentral Approved Drugs
3977
DrugMAP
DMP84CS
Enamine Bioactive Compounds
EBC-03969
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-W050154
NPC Screening Collection
Selleckchem Bioactive Compound Library
kojic-acid
TargetMol Bioactive Compound Library
T5889
ZINC Tool Compounds
ZINC000013831818
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
142.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.16
TPSA
70.67
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Parasite
Tyrosinase
CDK
NF-κB
Fungal,Tyrosinase
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
NF-¦ÊB
Source data