General
Preferred name
PIOGLITAZONE HYDROCHLORIDE
Synonyms
U-72107E ()
Pioglitazone (hydrochloride) ()
U 72107A ()
AD 4833 ()
Pioglitazone HCl ()
AD-4833, U-72107E ()
Actos ()
Pioglitazone (as hydrochloride) ()
Piomed ()
Diabiom ()
Glizofar ()
NSC-758876 ()
Glidipion ()
STR-001 ()
U-72107A ()
P&D ID
PD001166
CAS
111025-46-8
112529-15-4
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antidiabetic
First approval
1999
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective PPARgamma agonist; antidiabetic agent (Tocriscreen Plus)
DESCRIPTION Selective, high affinity PPARalpha agonist (Tocris Bioactive Compound Library)
Compound Sets
13
Axon Medchem Screening Library
3255
Cayman Chemical Bioactives
22263
ChEMBL Approved Drugs
CHEMBL1715
ChEMBL Drugs
CHEMBL1715
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101571
MedChem Express Bioactive Compound Library
HY-14601
NCATS Inxight Approved Drugs
JQT35NPK6C
NIH Clinical Collections (NCC)
Selleckchem Bioactive Compound Library
pioglitazone-hydrochloride-actos
The Spectrum Collection
Tocris Bioactive Compound Library
4124
Tocriscreen Plus
4124
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
392.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.58
TPSA
68.29
Fraction CSP3
0.32
Chiral centers
1.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Primary Target
PPAR?
MOA
Agonist
Target
PPAR? agonist
Ferroptosis
PPAR
Ferroptosis,P450 (e.g. CYP17),PPAR
Pathway
Apoptosis
Cell Cycle/DNA Damage
Vitamin D Related/Nuclear Receptor
Source data