General
Preferred name
DONEPEZIL HYDROCHLORIDE
Synonyms
E 2020 ()
Aricept ()
BNAG ()
E2020 ()
Donepezil HCl ()
Donepezil (Hydrochloride) ()
Aricept Odt ()
Aricept Evess ()
NSC-758882 ()
NSC-737535 ()
Adlarity ()
Donepezil hydrochloride component of namzaric ()
E-2020 ()
P&D ID
PD001165
CAS
120011-70-3
120014-06-4
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Cognitive impairment
First approval
1996
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on A¦Â42 neurotoxicity[2].
DESCRIPTION Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM). (TargetMol Bioactive Compound Library)
DESCRIPTION Potent O-GlcNAcase inhibitor (Tocris Bioactive Compound Library)
Compound Sets
13
AdooQ Bioactive Compound Library
A10330
Axon Medchem Screening Library
1438
ChEMBL Approved Drugs
CHEMBL1678
ChEMBL Drugs
CHEMBL1678
Ki Database
E 2020
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1678
MedChem Express Bioactive Compound Library
HY-B0034
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Donepezil-hydrochloride(Aricept)
TargetMol Bioactive Compound Library
T6478
The Spectrum Collection
Tocris Bioactive Compound Library
4385
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
415.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
4.78
TPSA
38.77
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
bAChE
hAChE
AChE inhibitor
Cholinesterase (ChE)
AChR
Primary Target
Cholinesterases
MOA
Inhibitor
Pathway
Neuroscience
Neuronal Signaling
Source data