General
Preferred name
picropodophyllin
Synonyms
PICROPODOPHYLLOTOXIN ()
AXL-1717 ()
Picropodophyllin, Picropodophyllotoxin ()
AXL1717 ()
PPP ()
Picropodophyllin (PPP)Picropodophyllotoxin ()
Picropodophyllin (PPP) ()
Picropodophyllotoxin ()
Podophyllotoxin picropodophyllin ()
Picropodophyllin ()
NSC-36407 ()
P&D ID
PD001163
CAS
17434-18-3
118627-04-6
477-47-4
Tags
available
drug candidate
Drug indication
non-small cell lung carcinoma
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
PRICE 72
PRICE 88
DESCRIPTION Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.
DESCRIPTION Picropodophyllin is a lignan extract from podophyllin resin produced in the roots of podophyllum plants. It is an epimer of picropodophyllotoxin. Picropodophyllin has been suggested to act as a selective inhibitor of the insulin-like growth factor 1 receptor (IGF1R) and has potential antineoplastic activity . Its effect via IGF1R have been questioned . (GtoPdb)
DESCRIPTION Insulin-like growth factor-I (IGF-I) receptor kinase inhibitor. (LOPAC library)
DESCRIPTION Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). (TargetMol Bioactive Compound Library)
DESCRIPTION Potent, broad spectrum MMP inhibitor (Tocris Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
A12195
BOC Sciences Bioactive Compounds
picropodophyllin-cas-477-47-4-373185
ChEMBL Drugs
CHEMBL283120
Clinical kinase drugs
DrugBank
DB12802
DrugMAP
DMTQ1Y3
Guide to Pharmacology
7873
LOPAC library
MedChem Express Bioactive Compound Library
HY-15494
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
picropodophyllin-ppp
TargetMol Bioactive Compound Library
T6943
The Spectrum Collection
Tocris Bioactive Compound Library
2956
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
414.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
2.41
TPSA
92.68
Fraction CSP3
0.41
Chiral centers
4.0
Largest ring
6.0
QED
0.76
Structural alerts
1
Tubulin modulation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
IGF-I kinase
Targets
IGF1R
Target
Apoptosis
IGF-1R
Apoptosis related,IGF-1R
Primary Target
Insulin and Insulin-like Receptors
MOA
Inhibitor
CASP3 activator
Apoptosis inhibitor
IGF1R inhibitor
IGF-1R Inhibitors
Caspase 3 Activators
Apoptosis Inducers
Member status
member
Pathway
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Source data