General
Preferred name
CHLOROBUTANOL
Synonyms
Clorbutol ()
Chlorbutol hemihydrate ()
Chlortran ()
Chloretone ()
YM-57158 ()
Chlorbutol ()
Chloreton ()
Chlorbutol, Chloreton, Chloretone, Chlortran| ()
CHLORBUTANOL ()
Chlorobutanol (hemihydrate) ()
Chlorbutol, Chloreton, Chloretone, Chlortran ()
Chlorobutanol hemihydrate ()
Clorobutanol ()
Anhydrous chlorobutanol ()
NSC-44794 ()
Chlorobutanolum ()
Chlorobutanol, anhydrous ()
P&D ID
PD001119
CAS
57-15-8
28471-22-9
6001-64-5
Tags
available
drug
Approved by
FDA
Drug Status
vet_approved
approved
investigational
Max Phase
2.0
Drug indication
Nausea
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry[1][2][3][4].
PRICE
110
DESCRIPTION
Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries[1][2][3][4][5].
PRICE
29
DESCRIPTION
Chlorobutanol is a detergent preservative with a broad spectrum of antimicrobial activity. Chlorobutanol disrupts the lipid structure of the cell membrane and increases the cell permeability, leading to cell lysis. It inhibits potassium voltage-gated channel subfamily H member 2.
(Enamine Bioactive Compounds)
DESCRIPTION
Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic. It has Antibacterial and Antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long-term stability to multi-ingredient formulations.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Chlorobutanol hemihydrate (Chlorbutol hemihydrate) is an orally toxic preservative with antimicrobial activity that inhibits Gram-positive and Gram-negative bacteria and fungi, inhibits the aggregation and release of human platelets in vitro, and is commonly used in cosmetics.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
175.96
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
2.13
TPSA
20.23
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Microbiology&virology
Anti-infection
Target
antibiotic
Bacterial
Fungal
MOA
Antibiotic
Indication
anesthetic, sedative
Source data
