General
Preferred name
ETHENZAMIDE
Synonyms
Anovigam ()
2-Ethoxybenzamide ()
J3.352I ()
NSC-28787 ()
O-ethoxybenzamide ()
Etenzamida ()
P&D ID
PD001114
CAS
938-73-8
Tags
available
drug
Drug Status
approved
experimental
investigational
Max Phase
2.0
Drug indication
Pain
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation. 2-Ethoxybenzamide can be used in the research of hypopigmentation and inflammation-related diseases[1][2].
PRICE 29
DESCRIPTION 2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug. It is used to reduce the fever, headaches, and other minor aches and pains. It is an ingredient in numerous cold medications and many prescription analgesics. (BOC Sciences Bioactive Compounds)
DESCRIPTION 2-Ethoxybenzamide is widely used as an antipyretic anodyne. It binds to the 5-hydroxytryptamine (5HT)2B receptor in concentration-dependent manner with modest inhibitory effects on monoamine oxidase-A and transient potential vanilloid 1 channel. (Enamine Bioactive Compounds)
DESCRIPTION 2-Ethoxybenzamide (Anovigam) is white or almost-white crystalline powder. Almost odorless. Tasteless. It is widely used as an antipyretic anodyne. (TargetMol Bioactive Compound Library)
Compound Sets
13
BOC Sciences Bioactive Compounds
2-ethoxybenzamide-cas-938-73-8-79842
ChEMBL Drugs
CHEMBL1483877
Drug Repurposing Hub
DrugBank
DB13544
DrugCentral
1080
DrugCentral Approved Drugs
1080
Enamine Bioactive Compounds
EBC-44318
MedChem Express Bioactive Compound Library
HY-B1428
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
2-ethoxybenzamide
TargetMol Bioactive Compound Library
T0058
The Spectrum Collection
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
165.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.18
TPSA
52.32
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
PERK
Reactive Oxygen Species (ROS)
Tyrosinase
Immunology & Inflammation related
Reactive Oxygen Species
Indication
headache, fever, common cold
Disease Area
neurology/psychiatry, endocrinology, otolaryngology
MOA
analgesic agent
Pathway
Immunology/Inflammation
Neuroscience
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
NF-κB
NF-¦ÊB
Solubility
DMSO : ≥ 47 mg/mL
Source data