General
Preferred name
AMIFOSTINE
Synonyms
WR2721 trihydrate ()
Ethyol ()
WR2721 ()
Gammaphos ()
WR 2721 ()
Amifostine (hydrate) ()
AMIFOSTINE ANHYDROUS ()
Amifostine (trihydrate) ()
WR2721 (trihydrate) ()
Amifostine hydrate ()
Amifostine trihydrate ()
AmifostineEthyolEthiofosAminopropylaminoethyl thiophosphate2-(3-Aminopropylamino)ethyl thiophosphateS-(2-(3-Aminopropylamino)ethyl) phosphorothioateS-[2-(3-Aminopropylamino)ethyl] phosphorothioateS-[2-[(3-Aminopropyl)amino]ethyl] dihydrogen phosphorothioateSAPEPWR 2721C ()
Amifostine (hydrate ()
Ethiofos ()
Amifostine disulfide ()
WR-2721 TRIHYDRATE ()
Amifostina ()
NSC-296961 ()
NSC-758236 ()
YM-08310 ()
WR-2721 ()
Ethiofos anhydrous ()
P&D ID
PD001085
CAS
112901-68-5
63717-27-1
644-99-5
20537-88-6
Tags
available
prodrug
drug
Approved by
FDA
First approval
1995
Drug indication
Mucositis
Myelodysplastic syndrome
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
PRICE
32
DESCRIPTION
Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Radioprotective agent; selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy
(LOPAC library)
DESCRIPTION
Amifostine is a cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
(Enamine Bioactive Compounds)
DESCRIPTION
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Amifostine hydrate is a radiation-protective agent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
27
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
NIH Mechanistic Set
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
59
Molecular Weight
214.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.25
TPSA
95.58
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.34
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cytoprotectant
Target
HIF/HIF Prolyl-Hydroxylase
MDM-2/p53
ALPPL2, ENPP1
Indication
renal toxicity
MOA
reducing agent
Pathway
Chromatin/Epigenetic
Metabolism
Apoptosis
Metabolic Enzyme/Protease
Source data
