General
Preferred name
Amrinone
Synonyms
INAMRINONE ()
Inocor ()
Wincoram ()
INAMRINONE LACTATE ()
Cordemcura ()
Cartonic ()
WIN 40680 ()
Vesistol ()
Amcoral ()
Amrinona ()
NSC-759805 ()
WIN-40680 ()
C01CE01 ()
Amrinone Lactate ()
P&D ID
PD001084
CAS
60719-84-8
75898-90-7
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Congestive heart failure
Cardiac disease
Cardiovascular disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Inamrinone is a phosphodiesterase inhibitor.
Marketed formulations may contain inamrinone lactate (PubChem CID 3035194). (GtoPdb)
DESCRIPTION Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent[1][2][3].
PRICE 29
DESCRIPTION Amrinone is a positive inotropic agent and phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. (Enamine Bioactive Compounds)
DESCRIPTION Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
26
ChEMBL Approved Drugs
CHEMBL12856
CHEMBL2096642
ChEMBL Drugs
CHEMBL12856
CHEMBL2096642
Concise Guide to Pharmacology 2017/18
7202
Concise Guide to Pharmacology 2019/20
7202
Concise Guide to Pharmacology 2021/22
7202
Concise Guide to Pharmacology 2023/24
7202
Drug Repurposing Hub
DrugBank
DB01427
DrugBank Approved Drugs
DB01427
DrugCentral
201
DrugCentral Approved Drugs
201
DrugMAP
DMRMFP4
DrugMAP Approved Drugs
DMRMFP4
DrugMatrix
Enamine Bioactive Compounds
EBC-12099
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS102183
Guide to Pharmacology
7202
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL12856
MedChem Express Bioactive Compound Library
HY-B1294
NCATS Inxight Approved Drugs
JUT23379TN
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T1265
The Spectrum Collection
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
187.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.02
TPSA
71.77
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PDE
phosphodiesterase
TNF-α
PDE3A, PDE3B, PDE4B, TNF
Phosphodiesterase (PDE)
Indication
congestive heart failure
MOA
phosphodiesterase inhibitor
Pathway
Apoptosis
Metabolism
Metabolic Enzyme/Protease
Therapeutic Class
Cardiovascular Agents
Source data