General
Preferred name
BENDROFLUMETHIAZIDE
Synonyms
Bendrofluazide ()
Bendroflumethiazide ()
Naturetin ()
Naturetin-10 ()
Urizide ()
Bendroflumethiazide component of corzide ()
Naturetin-5 ()
Centyl ()
Bendroflumetiazida ()
Berkozide ()
Naturetin-2.5 ()
Neo-Bendromax 5 ()
Aprinox ()
Neo-Bendromax 2.5 ()
NSC-758229 ()
Neo-Naclex ()
P&D ID
PD001076
CAS
73-48-3
Tags
available
drug
Approved by
FDA
First approval
1959
Drug indication
Cardiovascular disease
High blood pressure
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2].
DESCRIPTION
Bendroflumethiazide is a thiazide diuretic.
(GtoPdb)
DESCRIPTION
Bendroflumethiazide is a diuretic used to suppress lactation and to treat hypertension and edema.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
421.04
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
1.63
TPSA
118.36
Fraction CSP3
0.2
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NKCC
Therapeutic Class
Antihypertensive Agents
Pathway
Membrane Transporter/Ion Channel
Source data
