General
Preferred name
VINPOCETINE
Synonyms
Ethyl apovincaminate ()
RGH-4405 ()
RGH-4405,Ethyl apovincaminate,AY 27255 ()
Rgh 4405 ()
Vinporal ()
NSC-760093 ()
Cavinton ()
Ultra-vinca ()
Ethyl apovincamin-22-oate ()
Ceractin ()
AY-27255 ()
Tcv 3b ()
Bravinton ()
Apovincaminic acid ethyl ester ()
AY-27,255 ()
P&D ID
PD001069
CAS
42971-09-5
115986-87-3
Tags
natural product
drug
available
Drug indication
Ischemic stroke
Drug Status
investigational
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Vinpocetine is a semisynthetic derivative of the vinca alkaloid vincamine .
(GtoPdb)
DESCRIPTION
Ca2+ /calmodulin-dependent phosphodiesterase1 (PDE1) inhibitor.
(LOPAC library)
DESCRIPTION
NMDA antagonist; acts at ion channel site
(Tocris Bioactive Compound Library)
DESCRIPTION
Na+ channel blocker
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
25
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
350.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
2
cLogP
4.15
TPSA
34.47
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PDE I
Pathway
Membrane Transporter/Ion Channel
Metabolism
NF-??b
NF-¦ÊB
Metabolic Enzyme/Protease
NF-κB
Target
NF-??B
PDE
Sodium Channel
PDE1A, PDE1C
IKK
Phosphodiesterase (PDE)
Primary Target
Voltage-gated Sodium (NaV) Channels
MOA
Blocker
Nav1.8 (SNS/PN3) Sodium Channel Blockers
Phosphodiesterase I Inhibitors
phosphodiesterase inhibitor, sodium channel blocker
Member status
member
Indication
stroke, senile dementia
Therapeutic Class
Vasodilator Agents
Source data
