General
Preferred name
TRIFLUPROMAZINE HYDROCHLORIDE
Synonyms
Neoprin ()
Fluopromazine hydrochloride ()
Fluorofen ()
Flumazin ()
Vesprin ()
NSC-14959 ()
NSC-17473 ()
MC-4703 ()
Triflupromazine hcl ()
Triflupromazine (hydrochloride) ()
P&D ID
PD001067
CAS
1098-60-8
146-54-3
Tags
available
drug
Drug Status
approved
Max Phase
4.0
First approval
1957
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Triflupromazine hydrochloride is a phenothiazine with diverse biological activities. It is an antagonist of dopamine D2 receptor, also blocks sodium channel protein type 8 subunit alpha.
(Enamine Bioactive Compounds)
DESCRIPTION
D2 dopamine receptor antagonist; phenothiazine antipsychotic
(LOPAC library)
DESCRIPTION
The hydrochloride salt form of Triflupromazine, an analogue of Chlorpromazine, is effective as nntipsychotic drug and antemetic agent.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
Enamine BioReference Compounds
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
388.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
5.68
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Pathway
Autophagy
GPCR/G protein
Neuroscience
Solubility
DMSO:27mg/mL
Target
Dopamine Receptor
5-HT
dopamine
mAChR
Source data
