General
Preferred name
LEVOMENTHOL
Synonyms
(-)-menthol ()
Menthomenthol ()
Menthacamphor ()
L-Menthol ()
L-Menthol|Levomenthol|Menthomenthol|Menthacamphor ()
MENTHOL ()
DL-Menthol ()
RACEMENTHOL ()
L-Menthol, Levomenthol, Menthomenthol, Menthacamphor ()
(–)-Menthol ()
P&D ID
PD001064
CAS
2216-51-5
114376-98-6
89-78-1
Tags
natural product
drug
available
Approved by
FDA
Drug Status
investigational
approved
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthol induces a cooling sensation on the skin upon inhalation, oral ingestion, or topical application by stimulating the cold-sensitive receptors expressed on the skin, without actually causing a drop in the skin temperature.
DESCRIPTION Natural menthol principally occurs as the (-)-enantiomer, also known as levomenthol. This (-)-enantiomer is also one of the components of the INN-assigned racementhol. (GtoPdb)
Compound Sets
20
Cayman Chemical Bioactives
30384
ChEMBL Drugs
CHEMBL470670
Concise Guide to Pharmacology 2017/18
2430
Concise Guide to Pharmacology 2019/20
2430
Concise Guide to Pharmacology 2021/22
2430
Concise Guide to Pharmacology 2023/24
2430
Drug Repurposing Hub
DrugBank
DB00825
DrugBank Approved Drugs
DB00825
DrugCentral
934
DrugCentral Approved Drugs
934
Enamine BioReference Compounds
Guide to Pharmacology
2430
MedChem Express Bioactive Compound Library
HY-Y1683
NCATS Inxight Approved Drugs
BZ1R15MTK7
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
dl-menthol
-menthol
TargetMol Bioactive Compound Library
T1407
The Spectrum Collection
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
156.15
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
2.44
TPSA
20.23
Fraction CSP3
1.0
Chiral centers
3.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Target
Opioid Receptor
??-opioid receptor
OPRK1, TRPA1, TRPM8, TRPV3
GABA Receptor
TRP Channel
Member status
member
MOA
TRPM8 (TRP-p8
CMR1) Agonists
Indication
pain relief
Source data