General
Preferred name
DANTROLENE SODIUM
Synonyms
Dantrolene, sodium salt ()
Lapatinib ditosylate monohydrate ()
Dantrolene sodium salt ()
Dantrolene sodium hydrate ()
Dantrolene sodium hemiheptahydrate ()
Dantrolene sodium salt ()
Dantrolene (sodium hemiheptahydrate) ()
Dantrolene (sodium) ()
F 440 ()
F-440 ()
Ryanodex ()
Dantrolene sodium salt hemiheptahydrate ()
NSC-758403 ()
Dantrolene sodium heptahydrate ()
Dantrium ()
Dantrolen ()
Revonto ()
Dantamacrin ()
Dantrolene (sodium salt) ()
P&D ID
PD001049
CAS
24868-20-0
14663-23-1
7261-97-4
Tags
available
drug
Drug Status
approved
Max Phase
Phase 4
Drug indication
Relaxant (skeletal muscle)
First approval
1974
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibits intracellular Ca2+ release from the sarcoplasmic reticulum; muscle relaxant.
(LOPAC library)
DESCRIPTION
Non-competitive NMDA antagonist; also sigma ligand
(Tocris Bioactive Compound Library)
DESCRIPTION
Ca2+ release inhibitor
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
336.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.47
TPSA
120.12
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.25
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Release
Pathway
Membrane Transporter/Ion Channel
Autophagy
Neuronal Signaling
Target
Calcium Channel
Ryanodine receptor 1
ADC Cytotoxin,Calcium Channel
Primary Target
Ryanodine Receptors
MOA
Inhibitor
Source data
