General
Preferred name
METHAPYRILENE HYDROCHLORIDE
Synonyms
Methapyrilene (hydrochloride) ()
Thenylpyramine (hydrochloride) ()
Methapyrilene hcl ()
NSC-758410 ()
P&D ID
PD001037
CAS
135-23-9
91-80-5
Tags
drug
available
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo[2]
DESCRIPTION
H1 Histamine receptor antagonist
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
7
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
LOPAC library
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
297.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.13
TPSA
19.37
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Target
Histamine Receptor
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data
