General
Preferred name
AMSACRINE
Synonyms
AMSACRINE HYDROCHLORIDE ()
acridinyl anisidide hydrochloride ()
m-AMSA hydrochloride ()
AMSA ()
m-AMSA ()
CI-880 ()
acridinyl anisidide ()
amsacrine, Bristol-Myers ()
Amsacrine (hydrochloride) ()
m-AMSA, acridinyl anisidide ()
NSC-249992 ()
NSC-156303 ()
Amsidyl ()
SN-11841 ()
Amsidine ()
NCI-249992 ()
Amekrin ()
Amsidil ()
Acridinylanisidide ()
SN-21429 ()
Lamasine ()
Amsacrina ()
P&D ID
PD001019
CAS
54301-15-4
51264-14-3
Tags
available
drug
nuisance
First approval
1987
Drug indication
Acute lymphoblastic leukaemia
Neoplasm
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
PRICE 32
DESCRIPTION Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
PRICE 32
DESCRIPTION Amsacrine is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. (BOC Sciences Bioactive Compounds)
DESCRIPTION Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. (TargetMol Bioactive Compound Library)
DESCRIPTION DNA topoisomerase II inhibitor (LOPAC library)
DESCRIPTION Amsacrine hydrochloride is an antineoplastic agent which can intercalate into the DNA of tumor cells. It also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. (BOC Sciences Bioactive Compounds)
DESCRIPTION Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia. (TargetMol Bioactive Compound Library)
Cell lines
55
Organisms
3
Compound Sets
26
AdooQ Bioactive Compound Library
A13093
BOC Sciences Bioactive Compounds
amsacrine-cas-51264-14-3-item-84-93389
amsacrine-hydrochloride-cas-54301-15-4-374642
Cayman Chemical Bioactives
22223
ChEMBL Approved Drugs
CHEMBL43
ChEMBL Drugs
CHEMBL43
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00276
DrugBank Approved Drugs
DB00276
DrugCentral
203
DrugCentral Approved Drugs
203
DrugMAP
DMZKYIV
DrugMAP Approved Drugs
DMZKYIV
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100017
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL43
MedChem Express Bioactive Compound Library
HY-13551
HY-13551A
NIH Mechanistic Set
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
amsacrine-hydrochloride
TargetMol Bioactive Compound Library
T1206
T5820
The Spectrum Collection
ZINC Tool Compounds
ZINC000003812923
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
393.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
4
cLogP
4.51
TPSA
80.32
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
2
amino_acridine_A(46)
c:1:c:2:c(:c:c:c:1):n:c:3:c(:c:2-[#7]):c:c:c:c:3
PAINS Family B
Intercalation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
TopoII
Pathway
Autophagy
DNA Damage/DNA Repair
Membrane Transporter/Ion Channel
Cell Cycle/DNA Damage
Target
KCNH2, TOP2A
Topoisomerase
Potassium Channel
Topo II
Indication
acute lymphoblastic leukemia (ALL)
MOA
Topoisomerase inhibitor
Therapeutic Class
Anticancer Agents
Source data