General
Preferred name
CYCLOTHIAZIDE
Synonyms
NSC-758431 ()
Fluidil ()
Anhydron ()
35483 ()
P&D ID
PD001015
CAS
2259-96-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1982
Drug Status
approved
withdrawn
Drug indication
Congestive heart failure
Diuretic
Antihypertensive
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cyclothiazide functions primarily as an inhibior of the sodium-chloride symporter (SLC12A3) in distal convoluted tubules.
(GtoPdb)
DESCRIPTION
Blocks the rapid desensitization of AMPA glutamate receptors
(LOPAC library)
DESCRIPTION
AMPA selective desensitization inhibitor
(Tocriscreen Plus)
DESCRIPTION
Highly potent NMDA antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
AMPA selective desensitization inhibitor
(Tocriscreen Total)
DESCRIPTION
Cyclothiazide has been found to be a subunit-specific inhibitor of GABAC receptors and could be used as a diuretic agent as well as antihypertensive agent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
30
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
389.03
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
1.23
TPSA
118.36
Fraction CSP3
0.43
Chiral centers
4.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
AMPA
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Primary Target
AMPA Receptors
MOA
GluR
Modulator
AMPA Receptor Modulators
Member status
member
ATC
C03AA09
Therapeutic Class
Antihypertensive Agents
Target
iGluR
GABA Receptor
Source data
