General
Preferred name
NOCODAZOLE
Synonyms
R17934 ()
Oncodazole ()
Oncodazole, NSC238159 ()
Nocodazole (R17934) ()
Nocodazol ()
R-17934 ()
NSC-238159 ()
R 17,934 ()
P&D ID
PD001013
CAS
31430-18-9
Tags
available
drug candidate
nuisance
Drug Status
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to ¦Â-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.
PRICE 34
DESCRIPTION Cytotoxic agent (Tocris Bioactive Compound Library)
DESCRIPTION Microtubule inhibitor (Tocriscreen Plus)
DESCRIPTION Disrupts microtubules by binding to beta-tubulin (LOPAC library)
DESCRIPTION Microtubule inhibitor (Tocriscreen Total)
DESCRIPTION Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis. (TargetMol Bioactive Compound Library)
Cell lines
49
Organisms
4
Compound Sets
22
AdooQ Bioactive Compound Library
A13219
Cayman Chemical Bioactives
13857
ChEMBL Drugs
CHEMBL9514
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB08313
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100922
LOPAC library
MedChem Express Bioactive Compound Library
HY-13520
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
Selleckchem Bioactive Compound Library
nocodazole
TargetMol Bioactive Compound Library
T2802
The Spectrum Collection
Tocris Bioactive Compound Library
1228
Tocriscreen Plus
1228
Tocriscreen Total
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
301.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.03
TPSA
84.08
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
1
Tubulin modulation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Selectivity
beta-tubulin
Pathway
Angiogenesis
Apoptosis
Autophagy
Cytoskeletal Signaling
DNA Damage/DNA Repair
Tyrosine Kinase/Adaptors
Cell Cycle/DNA Damage
cytoskeleton
Protein Tyrosine Kinase/RTK
Primary Target
Microtubules
Member status
member
MOA
tubulin polymerization inhibitor
Antimitotic Drugs
Tubulin Polymerization Inhibitors
Tubulin modulator
"Tubulin polymerization inhibitor
Tubulin modulator"
Target
hPGDS
Bcr-Abl
Microtubule/Tubulin
Apoptosis related,Autophagy,Bcr-Abl,CRISPR/Cas9,Microtubule Associated
ABL
Abl (E255K)
ABL (T315I)
CRISPR/Cas9
Microtubule
Cellular injury category
Cytoskeletal
Source data