General
Preferred name
THIOTEPA
Synonyms
Tiofosyl ()
Triethylenethiophosphoramide ()
Tiofosfamid ()
Thio-TEPA ()
Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide ()
ThiotepaThioplexTriethylene thiophosphoramideThiophosphamideTSPATriethylenethiophosphoramideTris(ethylenimino)thiophosphateThiotriethylenephosphoramideThio-tepaTriaziridinylphosphine sulfide ()
Tiotepa ()
Thiotepa riemser ()
Tepadina ()
Thioplex ()
NSC-6396 ()
Tepylute ()
P&D ID
PD000999
CAS
52-24-4
1631739-26-8
Tags
available
drug
nuisance
Approved by
FDA
PMDA
EMA
First approval
1959
Drug indication
Breast cancer
Osteosarcoma
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Thiotepa is an organophosphorus DNA alkylating anti-cancer chemotherapeutic .
(GtoPdb)
DESCRIPTION
Thio-TEPA is a DNA alkylating agent, with antitumor activity.
PRICE
29
DESCRIPTION
Thiotepa is an alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas.
(Enamine Bioactive Compounds)
DESCRIPTION
Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
0
Compound Sets
28
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
189.05
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
0
cLogP
0.16
TPSA
9.03
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
3.0
QED
0.46
Structural alerts
1
Genotoxic
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
MOA
DNA alkylator
Cytochrome P450 Oxidase Inhibitors
DNA alkylating agent
Cytochrome P450 inhibitor
Target
DNA
antibiotic
Bacterial
DNA alkylation
DNA alkylator/crosslinker
CYP2B6, CYP3A4
Antineoplastic and Immunosuppressive Antibiotics
Member status
member
Indication
breast cancer, ovarian cancer, bladder cancer
Pathway
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Source data
