General
Preferred name
PIPOBROMAN
Synonyms
Abbott brand of pipobroman ()
Vercyte ()
Amedel ()
A-8103 ()
Pipobroman ()
1,4-Bis(3-bromopropionyl)piperazine ()
N,N'-Bis(3-bromopropionyl)piperazine ()
A 1803 ()
NSC-25154 ()
WLN: T6N DNTJ AV2E DV2E ()
Piperazine, 1,4-bis(3-bromo-1-oxopropyl)- ()
PB, Vercyte ()
P&D ID
PD000989
CAS
54-91-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1966
Drug Status
approved
withdrawn
Drug indication
Refractory chronic myeloid leukaemia
Antineoplastic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This is a DNA alkylating agent. (GtoPdb)
DESCRIPTION Pipobroman (trade names Vercite, Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. It is marketed by Abbott Laboratories. Pipobroman (PB) has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). (BOC Sciences Bioactive Compounds)
Compound Sets
21
BOC Sciences Bioactive Compounds
pipobroman-cas-54-91-1-item-84-465332
ChEMBL Approved Drugs
CHEMBL1585
ChEMBL Drugs
CHEMBL1585
Drug Repurposing Hub
DrugBank
DB00236
DrugBank Approved Drugs
DB00236
DrugCentral
2192
DrugCentral Approved Drugs
2192
DrugMAP
DMNL0E6
DrugMAP Approved Drugs
DMNL0E6
DrugMatrix
Guide to Pharmacology
7271
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1585
MedChem Express Bioactive Compound Library
HY-16398
NIH Approved Oncology Drugs
86412
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
pipobroman
TargetMol Bioactive Compound Library
T4570
The Spectrum Collection
Withdrawn 2.0
367
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
353.96
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
0
cLogP
1.23
TPSA
40.62
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
polycythemia vera, thrombocythemia
MOA
DNA alkylating agent
ATC
L01AX02
Therapeutic Class
Anticancer Agents
Pathway
Cell Cycle/DNA Damage
Target
DNA alkylator/crosslinker
DNA alkylator
Source data