General
Preferred name
NMDA
Synonyms
N-METHYL-D-ASPARTIC ACID ()
2-Methylamino-succinic acid(NMDA) ()
NMDA (N-Methyl-D-aspartic acid) ()
N-METHYL-D-ASPARTIC ACID (NMDA) ()
2-Methylamino-Succinic Acid ()
(R)-2-(Methylamino)Succinic Acid ()
N-Methyl-Daspartate ()
P&D ID
PD000968
CAS
6384-92-5
Tags
available
drug candidate
Drug indication
Discovery agent
Borderline personality disorder
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
NMDA glutamate receptor agonist
(LOPAC library)
DESCRIPTION
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
18
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
147.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.87
TPSA
86.63
Fraction CSP3
0.6
Chiral centers
1.0
Largest ring
0.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Target
GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D
NMDA agonist
Endogenous Metabolite
iGluR
NMDAR
NMDA Receptor
MOA
glutamate receptor agonist
Source data
