General
Preferred name
PD000946
Synonyms
6-AMINONICOTINAMIDE ()
6AN ()
P&D ID
PD000946
CAS
329-89-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 ¦ÌM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells[1][2][3][4].
PRICE 29
DESCRIPTION 6-Aminonicotinamide is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase. (Enamine Bioactive Compounds)
DESCRIPTION 6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide is a PGD inhibitor and apoptosis inducer. (BOC Sciences Bioactive Compounds)
DESCRIPTION 6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme. (TargetMol Bioactive Compound Library)
Compound Sets
7
BOC Sciences Bioactive Compounds
6-aminonicotinamide-cas-329-89-5-292088
Cayman Chemical Bioactives
10009315
Enamine Bioactive Compounds
EBC-48159
MedChem Express Bioactive Compound Library
HY-W010342
Selleckchem Bioactive Compound Library
6-aminonicotinamide
TargetMol Bioactive Compound Library
T7545
The Spectrum Collection
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
137.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.24
TPSA
82.0
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
NADP+-dependent enzyme
NADPH oxidase
Dehydrogenase
Pathway
Metabolic Enzyme/Protease
Source data