General
Preferred name
PROTIONAMIDE
Synonyms
Protionamidum ()
1321-TH ()
Prothionamide ()
Prothionamide, 1321-TH ()
Peteha ()
NSC-758962 ()
Trevintix ()
Protionamida ()
RP-9778 ()
RP 9778 ()
TH-1321 ()
Ektebin ()
P&D ID
PD000945
CAS
14222-60-7
Tags
available
drug
Drug indication
Tuberculosis
Drug Status
investigational
withdrawn
approved
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 ¦ÌM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 ¦Ìg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy[1][2][3][4][5].
PRICE
29
DESCRIPTION
An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
180.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.67
TPSA
38.91
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
MOA
Antibiotic
Indication
tuberculosis
Pathway
Microbiology/virology
Anti-infection
Therapeutic Class
Antituberculosis Agents
Source data
