General
Preferred name
CEPHARANTHINE
Synonyms
NSC-623442 ()
(+)-Cepharanthine ()
P&D ID
PD000940
CAS
481-49-2
Tags
available
drug
Approved by
PMDA
First approval
1951
Drug indication
Thrombocytopenia
COVID-19
Drug Status
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46 ¦ÌM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8].
DESCRIPTION Cepharanthine (NSC-623442) is a natural alkaloid that inhibits TNF-??-mediated NF??B stimulation, plasma membrane lipid peroxidation, and platelet aggregation, as well as cytokine production. Cepharanthine exhibits anti-inflammatory, antioxidant, and antitumor activities.
DESCRIPTION Cepharanthine (NSC-623442) is a natural alkaloid that inhibits TNF-α-mediated NFκB stimulation, plasma membrane lipid peroxidation, and platelet aggregation, as well as cytokine production. Cepharanthine exhibits anti-inflammatory, antioxidant, and antitumor activities. (TargetMol Bioactive Compound Library)
Cell lines
13
Organisms
3
Compound Sets
14
Cayman Chemical Bioactives
19648
ChEMBL Drugs
CHEMBL449782
Drug Repurposing Hub
DrugBank
DB16824
DrugCentral
5375
DrugCentral Approved Drugs
5375
DrugMAP
DM9Y5JB
DrugMAP Approved Drugs
DM9Y5JB
MedChem Express Bioactive Compound Library
HY-N6972
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
cepharanthine
TargetMol Bioactive Compound Library
T0131
The Spectrum Collection
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
606.27
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
9
Aromatic Ring Count
4
cLogP
6.87
TPSA
61.86
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
18.0
QED
0.25
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
MOA
TNF
NFkB pathway inhibitor
Target
TNF-¦Á
Cytochrome P450
Parasite
SARS-CoV
TNF-alpha
HIV
TNF-α
Source data