General
Preferred name
TRANILAST
Synonyms
Sodium Tranilast ()
MK 341 Sodium ()
SB 252218 Sodium ()
MK 341 ()
Tranilast (Sodium) ()
Tranilast (trans-) ()
Tranilast trans- ()
Trans-Tranilast ()
Tranilast (SB 252218) ()
trans-MK-341 ()
trans-SB 252218 ()
MK-341 ()
SB 252218 ()
SB 252218, MK-341, Rizaben, MK 341, Tranpro ()
Rizaben ()
NSC-758970 ()
P&D ID
PD000929
CAS
70806-55-2
053902-12-8
53902-12-8
Tags
natural product
drug
available
Drug indication
Ocular allergy
Anti-Asthmatic
Drug Status
investigational
approved
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tranilast is an anti-allergic drug, with a complex mechanism of action , and potential antiproliferative activity .
(GtoPdb)
DESCRIPTION
Antagonist of mitochondrial Na+/Ca2+ exchange
(Tocris Bioactive Compound Library)
DESCRIPTION
Antiallergic; inhibits inflammatory mediator release from mast cells
(Tocriscreen Plus)
DESCRIPTION
Inhibits LTC4 and PGE2 formation but does not inhibit cyclooxygenase or lipoxygenase activity; anti-asthma drug
(LOPAC library)
DESCRIPTION
Antiallergic, inhibits release from mast cells
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
26
AdooQ Bioactive Compound Library
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
LOPAC library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
327.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.05
TPSA
84.86
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Other Pharmacology
Selectivity
LTC4
Target
Angiotensin Receptor
HPGDS, HRH1
hPGDS
Prostaglandin Receptor
Immunology & Inflammation related
Pathway
GPCR/G protein
Endocrinology/Hormones
Primary Target
Miscellaneous Compounds
Member status
member
MOA
IL-10 Production Enhancers
IL-2 Production Inhibitors
IL-4 Modulators
Indoleamine 2,3-dioxygenase Activators
Signal Transduction Modulators
TNF-alpha Production Inhibitors
IFN-gamma Production Inhibitors
Urate Transporter 1 (URAT1) Inhibitors
angiogenesis inhibitor
Indication
asthma
Source data
