General
Preferred name
MODAFINIL
Synonyms
Cep-1538 ()
ARMODAFINIL ()
NSC-759110 ()
CRL-40476 ()
Provigil ()
Modiodal ()
Modafinil civ ()
THN-102 COMPONENT MODAFINIL ()
THN102 COMPONENT MODAFINIL ()
Modaphonil ()
DEP-1538 ()
NSC-751178 ()
CEP 1538 ()
CRL 40476 ()
CRC-40476 ()
P&D ID
PD000912
CAS
112111-49-6
68693-11-8
Tags
natural product
drug
available
Approved by
PMDA
FDA
First approval
1998
Drug Status
investigational
approved
Drug indication
Brain injury
Analeptic (treatment of narcolepsy hypersomnia)
Bipolar disorder
Narcolepsy
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Modafinil is a eugeroic (wakefulness-promoting) drug with a multi-faceted mechanism of action. In some jurisdictions this drug is classified as a controlled substance due to its possible addiction potential. It has been termed a 'smart' drug, a group of prescription medications, purchased illegally or used off-label, with alleged cognition-enhancing properties .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
22
Axon Medchem Screening Library
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
273.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
2.01
TPSA
60.16
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine Transporter
a1 agonist
MOA
dopamine transporter inhibitor
alpha1-Adrenoceptor Agonists
Member status
virtual
Therapeutic Class
Neurology Agents
Source data
