General
Preferred name
SEVOFLURANE
Synonyms
FLUOROMETHYL 2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL)ETHYL ETHER ()
Sojourn ()
MR6S4 ()
Sevorane ()
MR-6S4 ()
Ultane ()
Sevocalm ()
Sevoflo ()
NSC-760367 ()
P&D ID
PD000891
CAS
28523-86-6
Tags
available
drug
Approved by
FDA
First approval
1995
Drug Status
approved
vet_approved
Drug indication
Anesthetic (inhalation)
Anaesthesia
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sevoflurane is a highly fluorinated methyl isopropyl ether inhalational anaesthetic, and it is one of the most commonly used inhalational anaesthetics. After , it is the volatile anaesthetic with the fastest onset and offset . (GtoPdb)
PHARMACODYNAMICS Sevoflurane induces muscle relaxation and reduces pains sensitivity by altering tissue excitability with a fast onset of action. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Compound Sets
15
Cayman Chemical Bioactives
23996
ChEMBL Approved Drugs
CHEMBL1200694
ChEMBL Drugs
CHEMBL1200694
Drug Repurposing Hub
DrugBank
DB01236
DrugBank Approved Drugs
DB01236
DrugCentral
2439
DrugCentral Approved Drugs
2439
DrugMAP
DMC9O43
DrugMAP Approved Drugs
DMC9O43
DrugMatrix
Guide to Pharmacology
7296
NCATS Inxight Approved Drugs
38LVP0K73A
NPC Screening Collection
ReFrame library
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
200.01
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
2.42
TPSA
9.23
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ATP2C1, ATP5D, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GLRA1, GLRB, GRIA1, KCNA1, KCNK10, KCNK18, KCNK2, KCNK3, KCNK9, MT-ND1
Indication
anesthetic
MOA
membrane integrity inhibitor
Therapeutic Class
Anesthetics
Source data