General
Preferred name
MEPHENYTOIN
Synonyms
Mesantoin ()
Methoin ()
Insulton ()
Phenantoin ()
Methylphenetoin ()
(S)-Mephenytoin ()
NSC-34652 ()
Mephenytoine ()
Mefenitoina ()
P&D ID
PD000886
CAS
50-12-4
70989-04-7
Tags
available
drug
Approved by
FDA
First approval
1946
Drug indication
Epilepsy
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].
PRICE
78
PRICE
110
DESCRIPTION
Mephenytoin is a hydantoin class drug. It is no longer available in the US or the UK.
(GtoPdb)
DESCRIPTION
Mephenytoin is an anticonvulsant. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and Cytochrome P450 2D6 are known to metabolize mephenytoin.
(Enamine Bioactive Compounds)
DESCRIPTION
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.
(TargetMol Bioactive Compound Library)
DESCRIPTION
(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant that serves as a substrate of the cytochrome P450 (CYP) isoform CYP2C19 and is used to analyze cytochrome P450 metabolism.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent and selective 11beta-hydroxysteroid dehydrogenase inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
218.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
1.47
TPSA
49.41
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
voltage-gated sodium channel blocker
Substrate
Target
Sodium channel alpha subunit
CYP2B6
CYP2C19
Primary Target
Cytochrome P450
Therapeutic Class
Anticonvulsants
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
