General
Preferred name
ISOSORBIDE MONONITRATE
Synonyms
isosorbide mononitrate, Hassle ()
Isosorbide-5-mononitrate ()
Isosorbide-5-mononitrate, Elantan, Monoket, Mononit, Imdur, Corangin ()
Astrodur MR ()
Monit SR ()
Imo LA ()
Isosorbide 5-nitrate ()
BM-22145 ()
Dynamin ()
Eumon 40 XL ()
Cibral 10 ()
Monosorb XL 60 ()
Cibral 40 ()
Ismo Ret ()
Elantan LA 25 ()
Cibral 20 ()
Relosorb XL ()
Isosorbide dinitrate isosorbide-5-mononitrate ()
IS-5-MN ()
Trangina XL ()
Angeze SR 60 ()
Mono-Cedocard 10 ()
BM-22.145 ()
Monomax SR 40 ()
Vasotrate 60 SR ()
Angeze SR 40 ()
Angeze 10 ()
Elantan LA 50 ()
Isotrate ()
Isosorbide 5-mononitrate ()
Isobutyldiurea ()
MCR 50 ()
Monodur ()
Elantan 10 ()
Dynamin XL 50 ()
Isib 40 ()
Xismox XL 60 ()
Isib 20 ()
Isib 60 XL ()
Angeze 40 ()
Diluted isosorbide mononitrate ()
Zemon 40 XL ()
IS 5-MN ()
Isobutylenediurea ()
Angeze 20 ()
Angitate ()
Isotard 60 XL ()
Dynamin XL 25 ()
Monoket ()
Mono-Cedocard 40 ()
Isodur 25 XL ()
Monigen XL 60 ()
Monit XL 60 ()
BM-22-145 ()
Ismo 20 ()
Modisal 60 XL ()
Monit ()
Mononitrato de isosorbida ()
1,1-diureidisobutane ()
Iso-5-mononitrate ()
Eumon 60 XL ()
Chemydur 60 XL ()
Isodur 50 XL ()
Ziotan XL ()
IS-5MN ()
BM 22.145IS 5-MNAHR-4698 ()
Elantan 20 ()
Imdur ()
Slomon XL 60 ()
Carmil XL ()
Monomax XL ()
Ismo 10 ()
Ketanodur ()
Tardisc XL ()
Modisal LA 50 ()
Mono-Cedocard 20 ()
Mononitrate d'isosorbide ()
Phasonit LA 50 ()
Elantan 40 ()
Isotard 40 XL ()
Tenkosorb ()
Modisal LA 25 ()
Monocord ()
Cibral XL 60 ()
Corangin ()
Monomax SR 60 ()
Zemon 60 XL ()
Pertil Ret ()
Isotard 50 XL ()
Isodur ()
Monit LS ()
NSC-758619 ()
Isib 50 XL ()
ISMO ()
Monomil XL ()
AHR-4698 ()
Modisal 40 XL ()
Ismo 40 ()
BM 22.145 ()
Isotard 25 XL ()
P&D ID
PD000864
CAS
16051-77-7
Tags
available
prodrug
drug
Approved by
FDA
First approval
1991
Drug indication
Hypertension
Hydrocephalus
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE Isosorbide mononitrate is primarily metabolized by the liver, but unlike oral isosorbide dinitrate, it is not subject to first-pass metabolism.; Isosorbide mononitrate is cleared by denitration to isosorbide and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 days and only about 1% eliminated in the feces. At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites.
DESCRIPTION Isosorbide mononitrate is termed a nitrate drug and acts as a vasodilator. It is similar to nitroglycerin, but is slower to act. (GtoPdb)
DESCRIPTION Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].
Cell lines
0
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
A15952
ChEMBL Approved Drugs
CHEMBL1311
ChEMBL Drugs
CHEMBL1311
Drug Repurposing Hub
DrugBank
DB01020
DrugBank Approved Drugs
DB01020
DrugCentral
1506
DrugCentral Approved Drugs
1506
DrugMAP
DMYLMU0
DrugMAP Approved Drugs
DMYLMU0
Guide to Pharmacology
7052
MedChem Express Bioactive Compound Library
HY-B0642
NCATS Inxight Approved Drugs
LX1OH63030
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
isosorbide-mononitrate
The Spectrum Collection
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
191.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.28
TPSA
91.06
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
5.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
angina pectoris, coronary artery disease (CAD)
Target
GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3
Apoptosis
Autophagy
Endogenous Metabolite
MOA
nitric oxide stimulant
Therapeutic Class
Vasodilator Agents
Pathway
Metabolic Enzyme/Protease
Source data