General
Preferred name
ISOSORBIDE MONONITRATE
Synonyms
isosorbide mononitrate, Hassle ()
Isosorbide-5-mononitrate ()
Isosorbide-5-mononitrate, Elantan, Monoket, Mononit, Imdur, Corangin ()
Modisal LA 50 ()
Angeze SR 40 ()
IS-5-MN ()
Xismox XL 60 ()
Isib 60 XL ()
Ziotan XL ()
Elantan 40 ()
Zemon 60 XL ()
Elantan LA 50 ()
BM-22145 ()
Imo LA ()
Angeze 40 ()
Ismo 20 ()
Eumon 40 XL ()
Isosorbide 5-mononitrate ()
ISMO ()
AHR-4698 ()
Mono-Cedocard 10 ()
IS-5MN ()
Isotard 50 XL ()
Imdur ()
Isib 50 XL ()
Cibral 40 ()
Monomax XL ()
Trangina XL ()
Tardisc XL ()
Angitate ()
Mono-Cedocard 40 ()
Isib 40 ()
Phasonit LA 50 ()
BM-22.145 ()
Dynamin XL 25 ()
Vasotrate 60 SR ()
NSC-758619 ()
Isobutyldiurea ()
Elantan 20 ()
Isodur 50 XL ()
Monit ()
Isodur ()
Ismo 10 ()
IS 5-MN ()
Cibral 10 ()
Cibral XL 60 ()
Modisal 60 XL ()
Monomax SR 60 ()
Monomax SR 40 ()
Corangin ()
Eumon 60 XL ()
Carmil XL ()
Tenkosorb ()
Monit XL 60 ()
Isosorbide dinitrate isosorbide-5-mononitrate ()
Diluted isosorbide mononitrate ()
Isib 20 ()
Monosorb XL 60 ()
Isosorbide 5-nitrate ()
Isobutylenediurea ()
Isotard 25 XL ()
Isotrate ()
Dynamin XL 50 ()
Elantan LA 25 ()
Slomon XL 60 ()
Cibral 20 ()
Zemon 40 XL ()
Monodur ()
BM 22.145IS 5-MNAHR-4698 ()
MCR 50 ()
Pertil Ret ()
Isotard 40 XL ()
1,1-diureidisobutane ()
Astrodur MR ()
Monoket ()
Dynamin ()
Angeze 10 ()
Iso-5-mononitrate ()
Chemydur 60 XL ()
Monigen XL 60 ()
BM 22.145 ()
Ismo Ret ()
Monomil XL ()
Isodur 25 XL ()
Ketanodur ()
Ismo 40 ()
Monit LS ()
Mono-Cedocard 20 ()
Elantan 10 ()
BM-22-145 ()
Modisal 40 XL ()
Monit SR ()
Angeze 20 ()
Angeze SR 60 ()
Isotard 60 XL ()
Modisal LA 25 ()
Monocord ()
Relosorb XL ()
P&D ID
PD000864
CAS
16051-77-7
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1991
Drug Status
approved
Drug indication
Vasodilator (coronary)
Hydrocephalus
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isosorbide mononitrate is termed a nitrate drug and acts as a vasodilator. It is similar to nitroglycerin, but is slower to act. (GtoPdb)
ROE Isosorbide mononitrate is primarily metabolized by the liver, but unlike oral isosorbide dinitrate, it is not subject to first-pass metabolism.; Isosorbide mononitrate is cleared by denitration to isosorbide and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 days and only about 1% eliminated in the feces. At least six different compounds have been detected in urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites.
Cell lines
0
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
A15952
ChEMBL Approved Drugs
CHEMBL1311
ChEMBL Drugs
CHEMBL1311
Drug Repurposing Hub
DrugBank
DB01020
DrugBank Approved Drugs
DB01020
DrugCentral
1506
DrugCentral Approved Drugs
1506
DrugMAP
DMYLMU0
DrugMAP Approved Drugs
DMYLMU0
Guide to Pharmacology
7052
MedChem Express Bioactive Compound Library
HY-B0642
NCATS Inxight Approved Drugs
LX1OH63030
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
isosorbide-mononitrate
The Spectrum Collection
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
191.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.28
TPSA
91.06
Fraction CSP3
1.0
Chiral centers
4.0
Largest ring
5.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
angina pectoris, coronary artery disease (CAD)
Target
GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3
Endogenous Metabolite
MOA
nitric oxide stimulant
Therapeutic Class
Vasodilator Agents
Pathway
Autophagy
Metabolic Enzyme/Protease
Source data