General
Preferred name
METHYCLOTHIAZIDE
Synonyms
METHYCHLOTHIAZIDE ()
methylclothiazide ()
NSC-110431 ()
Enduron ()
Aquatensen ()
P&D ID
PD000852
CAS
135-07-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1960
Drug indication
Diuretic
Hypertension
Antihypertensive
Edema
Drug Status
approved
withdrawn
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Methyclothiazide is a diuretic. (GtoPdb)
DESCRIPTION Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. (BOC Sciences Bioactive Compounds)
Compound Sets
18
BOC Sciences Bioactive Compounds
methyclothiazide-cas-135-07-9-item-84-57762
Cayman Chemical Bioactives
23799
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1577
ChEMBL Drugs
CHEMBL1577
DrugBank
DB00232
DrugCentral
1759
DrugCentral Approved Drugs
1759
DrugMAP
DMN7SDE
DrugMAP Approved Drugs
DMN7SDE
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7235
MedChem Express Bioactive Compound Library
HY-B0562
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
methyclothiazide
The Spectrum Collection
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
358.96
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
0.6
TPSA
109.57
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
thiazide sensitive sodium-chloride cotransporter inhibitor
Target
Thiazide-sensitive sodium-chloride cotransporter
Carbonic Anhydrase
Therapeutic Class
Antihypertensive Agents
Pathway
Metabolic Enzyme/Protease
Solubility
Soluble in DMSO (Slightly), Methanol (Slightly)
Source data