General
Preferred name
BENZONATATE
Synonyms
benzonatate polacrilex, Alitair ()
Benzononatine ()
NSC-760128 ()
Tessalon ()
P&D ID
PD000842
CAS
104-31-4
Tags
natural product
drug
available
Drug Status
approved
Drug indication
Cough
Antitussive
Max Phase
Phase 4
First approval
1958
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Benzonatate is a non-narcotic antitussive. It is classified as a butylamine compound, and has structural similatities to ester type local anesthetics (e.g. and tetracaine). It has reduced abuse potential compared to opioid-like antitussives. (GtoPdb)
Compound Sets
16
Cayman Chemical Bioactives
23936
ChEMBL Approved Drugs
CHEMBL1374379
ChEMBL Drugs
CHEMBL1374379
Drug Repurposing Hub
DrugBank
DB00868
DrugBank Approved Drugs
DB00868
DrugMAP
DM9U4FO
DrugMAP Approved Drugs
DM9U4FO
DrugMatrix
Guide to Pharmacology
7611
MedChem Express Bioactive Compound Library
HY-B1551
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T19644
The Spectrum Collection
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
603.36
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
1
Rotatable Bonds
32
Ring Count
1
Aromatic Ring Count
1
cLogP
2.83
TPSA
121.4
Fraction CSP3
0.77
Chiral centers
0.0
Largest ring
6.0
QED
0.1
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
Sodium Channel
SCN5A
Indication
cough suppressant
MOA
local anesthetic
Therapeutic Class
Antitussives
Source data