General
Preferred name
KETOROLAC TROMETHAMINE
Synonyms
Ketorolac tris salt ()
Toradol ()
Acular ()
Acular LS ()
Ketorolac (tromethamine salt) ()
RS37619 tromethamine salt ()
Ketorolac tromethamine salt ()
Lixidol ()
Acuvail ()
NSC-758637 ()
Dolac ()
Tarasyn ()
Ketorolac (+/-)-form tromethamine salt ()
Sprix ()
Acular preservative free ()
Ketorolac tromethamine component of omidria ()
Ketorolac trometamol ()
P&D ID
PD000805
CAS
74103-07-4
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Pain
First approval
1989
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
DESCRIPTION
Non-steroidal anti-inflammatory (NSAID) drug
(LOPAC library)
DESCRIPTION
Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and antipyretic activities.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
376.16
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.05
TPSA
146.01
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Target
COX-1
COX-2
Pathway
Immunology/Inflammation
Neuroscience
Source data
