General
Preferred name
PERPHENAZINE
Synonyms
Prednazate ()
Perphenazine (D8 Dihydrochloride) ()
Perphenazin ()
Trilafon ()
Etaperazine ()
Perphenazin, Trilafon, Etaperazine ()
Perphenazine Maleate ()
NSC-150866 ()
Fentazin ()
Perphenazine Fendizoate ()
Chlorpiprazine ()
Decentan ()
Trilafon-La ()
Perphenazine-d4 ()
P&D ID
PD000799
CAS
58-39-9
130-69-8
155593-75-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1957
Drug Status
approved
Drug indication
Antipsychotic
Schizophrenia
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Perphenazine is a typical antipsychotic drug, acting principally as a dopamine D2 receptor antagonist.
(GtoPdb)
DESCRIPTION
D2 dopamine receptor antagonist; sigma receptor agonist; phenothiazine antipsychotic
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
3
Compound Sets
33
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
403.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
3.94
TPSA
29.95
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Target
Dopamine Receptor
Histamine Receptor
Adrenergic Receptor
5-HT Receptor
CAM
dopamine
5-HT2Areceptor
Histamine H1 receptor
Alpha-1a adrenergic receptor
CALM1, DRD1, DRD2, HRH1, HTR2A, HTR2C, HTR6, HTR7
Pathway
GPCR/G protein
Neuronal Signaling
Immunology/Inflammation
Neuroscience
Apoptosis
Autophagy
Member status
virtual
MOA
Dopamine Receptor Antagonists
Dopamine Receptor antagonist
Indication
schizophrenia, nausea, vomiting
Disease Area
neurology/psychiatry, gastroenterology
Therapeutic Class
Antipsychotic Agents
Source data
