General
Preferred name
PROPAFENONE HYDROCHLORIDE
Synonyms
Propafenone (hydrochloride) ()
SA-79 (hydrochloride) ()
NSC-758640 ()
Arythmol ()
Rytmonorm ()
Rythmol ()
Rythmol Sr ()
Propafenone HCl ()
Propafenone (hydrochloride) ()
P&D ID
PD000798
CAS
34183-22-7
54063-53-5
163858-56-8
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Cardiac Depressant (anti-arrhythmic)
First approval
1989
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Blocks hKv1.5 and ATP-sensitive K+ channels; beta-adrenoceptor antagonist
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
8
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
377.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
11
Ring Count
2
Aromatic Ring Count
2
cLogP
3.66
TPSA
58.56
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
hKv1.5
Pathway
Membrane Transporter/Ion Channel
Target
Sodium Channel
Source data
