General
Preferred name
BAICALEIN
Synonyms
5,6,7-Trihydroxyflavone ()
Noroxylin ()
NSC-661431 ()
P&D ID
PD000773
CAS
491-67-8
Tags
available
drug candidate
natural product
nuisance
Drug indication
influenza
Influenza virus infection
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Baicalein suppresses (neuro)inflammation mediated by the NLRP3/caspase-1/GSDMD signalling pathway in vivo .
(GtoPdb)
DESCRIPTION
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 ¦ÌM.
PRICE
29
DESCRIPTION
Potent MEK1 inhibitor. Also inhibits IkappaBalpha phosphorylation
(Tocris Bioactive Compound Library)
DESCRIPTION
5- and 12-Lipoxygenase inhibitor
(Tocriscreen Total)
DESCRIPTION
Baicalein is a flavonoid originally isolated from the roots of S. baicalensis that has diverse biological activities. It inhibits human platelet 12-lipoxygenase and human reticulocyte 15-LO-1.
(Enamine Bioactive Compounds)
DESCRIPTION
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
12
Organisms
6
Compound Sets
20
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
IPPI - DB
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
270.05
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.58
TPSA
90.9
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Flavonoid
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
Ferroptosis
Influenza Virus
Xanthine oxidase
XO
P450 (e.g. CYP17),PREP
Primary Target
Lipoxygenases
MOA
Inhibitor
Pathway
Apoptosis
Immunology/Inflammation
Metabolism
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
Source data
