General
Preferred name
MYCOPHENOLATE MOFETIL
Synonyms
Mycophenolate ()
TM-MMF ()
RS 61443 ()
MYCOPHENOLATE MOFETIL HYDROCHLORIDE ()
Mycophenolate mofetil (RS-61443) ()
Mycophenolic acid morpholinoethyl ester, CellCept, RS 61443, TM-MMF ()
CellCept ()
Myclausen ()
Myfenax ()
NSC-758905 ()
Arzip ()
Mycophenolic acid 2-(4-morpholinyl)ethyl ester ()
NSC-724229 ()
Mycophenylate mofetil ()
RS-61443 ()
Mycophenolate mofetil hcl ()
RS-61443-190 ()
Mycophenolate Mofetil-d4 ()
P&D ID
PD000743
CAS
128794-94-5
116680-01-4
1132748-21-0
115007-34-6
Tags
prodrug
natural product
drug
available
Approved by
PMDA
EMA
FDA
First approval
1995
1998
Drug Status
investigational
approved
Drug indication
Immune System disease
Organ transplant rejection
Immunomodulator
Pemphigus vulgaris
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) (GtoPdb)
DESCRIPTION PARP-1 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Inosine monophosphate dehydrogenase inhibitor (Tocriscreen Plus)
DESCRIPTION Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. (BOC Sciences Bioactive Compounds)
Cell lines
3
Organisms
2
Compound Sets
23
AdooQ Bioactive Compound Library
A10613
Axon Medchem Screening Library
3498
BOC Sciences Bioactive Compounds
mycophenolate-mofetil-hydrochloride-cas-116680-01-4-item-84-186378
Cayman Chemical Bioactives
13988
25281
ChEMBL Approved Drugs
CHEMBL1456
CHEMBL1200955
ChEMBL Drugs
CHEMBL1456
CHEMBL1200955
Drug Repurposing Hub
DrugBank
DB00688
DrugBank Approved Drugs
DB00688
DrugCentral
1859
DrugCentral Approved Drugs
1859
DrugMAP
DMPQAGE
DrugMAP Approved Drugs
DMPQAGE
Guide to Pharmacology
6831
MedChem Express Bioactive Compound Library
HY-B0199
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Mycophenolate-mofetil-(CellCept)
TargetMol Bioactive Compound Library
T0245
T6293
The Spectrum Collection
Tocris Bioactive Compound Library
4102
Tocriscreen Plus
4102
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
433.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
1
cLogP
2.52
TPSA
94.53
Fraction CSP3
0.57
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Metabolism
Dehydrogenase
Anti-infection
Apoptosis
Metabolic Enzyme/Protease
Target
IMPDH
IMPDH1, IMPDH2
IMPDH inhibitor
Bacterial
Drug Metabolite
Endogenous Metabolite
Apoptosis related,Dehydrogenase
Primary Target
Other Dehydrogenases
MOA
Inhibitor
Nicotinic Acid (Niacin
GPR109A
HM74A) Receptor Agonists
Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors
dehydrogenase inhibitor, inositol monophosphatase inhibitor
Member status
member
Indication
organ rejection
Therapeutic Class
Immunosuppressive Agents
Source data