General
Preferred name
MYCOPHENOLATE MOFETIL
Synonyms
Mycophenolate ()
TM-MMF ()
RS 61443 ()
Mycophenolate mofetil (hydrochloride) ()
RS 61443 (hydrochloride) ()
TM-MMF (hydrochloride) ()
Mycophenolic acid morpholinoethyl ester, CellCept, RS 61443, TM-MMF ()
MYCOPHENOLATE MOFETIL HYDROCHLORIDE ()
Mycophenolate mofetil (RS-61443) ()
Mycophenolate Mofetil-d4 ()
Arzip ()
Mycophenolate mofetil teva ()
NSC-758905 ()
NSC-724229 ()
Mycophenolic acid 2-(4-morpholinyl)ethyl ester ()
Myclausen ()
CellCept ()
Myhibbin ()
Myfenax ()
Mycophenylate mofetil ()
RS-61443 ()
RS-61443-190 ()
Mycophenolate mofetil hcl ()
Cellcept hydrochloride ()
P&D ID
PD000743
CAS
128794-94-5
116680-01-4
1132748-21-0
115007-34-6
Tags
available
prodrug
drug
Approved by
EMA
PMDA
FDA
First approval
1998
1995
Drug indication
Immune System disease
IGA glomerulonephritis
Pemphigus vulgaris
Organ transplant rejection
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) (GtoPdb)
PRICE 29
DESCRIPTION Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].
DESCRIPTION RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
DESCRIPTION Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.
DESCRIPTION PARP-1 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Inosine monophosphate dehydrogenase inhibitor (Tocriscreen Plus)
DESCRIPTION Mycophenolate mofetil is an inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. (Enamine Bioactive Compounds)
DESCRIPTION Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH). (TargetMol Bioactive Compound Library)
DESCRIPTION Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. (BOC Sciences Bioactive Compounds)
Cell lines
3
Organisms
3
Compound Sets
24
AdooQ Bioactive Compound Library
A10613
Axon Medchem Screening Library
3498
BOC Sciences Bioactive Compounds
mycophenolate-mofetil-hydrochloride-cas-116680-01-4-item-84-186378
Cayman Chemical Bioactives
13988
25281
ChEMBL Approved Drugs
CHEMBL1456
CHEMBL1200955
ChEMBL Drugs
CHEMBL1456
CHEMBL1200955
Drug Repurposing Hub
DrugBank
DB00688
DrugBank Approved Drugs
DB00688
DrugCentral
1859
DrugCentral Approved Drugs
1859
DrugMAP
DMPQAGE
DrugMAP Approved Drugs
DMPQAGE
Enamine Bioactive Compounds
EBC-11251
Guide to Pharmacology
6831
MedChem Express Bioactive Compound Library
HY-B0199
HY-B0199A
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Mycophenolate-mofetil-(CellCept)
TargetMol Bioactive Compound Library
T6293
The Spectrum Collection
Tocris Bioactive Compound Library
4102
Tocriscreen Plus
4102
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
433.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
1
cLogP
2.52
TPSA
94.53
Fraction CSP3
0.57
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Apoptosis
Drug Metabolite
IMPDH
IMPDH1, IMPDH2
IMPDH inhibitor
Bacterial
Endogenous Metabolite
Apoptosis related,Dehydrogenase
Primary Target
Other Dehydrogenases
MOA
Inhibitor
Nicotinic Acid (Niacin
GPR109A
HM74A) Receptor Agonists
Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors
dehydrogenase inhibitor, inositol monophosphatase inhibitor
Member status
member
Indication
organ rejection
Pathway
Metabolism
Anti-infection
Metabolic Enzyme/Protease
Therapeutic Class
Immunosuppressive Agents
Source data